Potential of cancer-testis antigens as targets for cancer immunotherapy

نویسندگان

  • Parvin Mehdipour
  • Mohammad Hossein Modarressi
  • Soudeh Ghafouri-Fard
  • Mohammad-Hossein Modarressi
چکیده

Cancer-testis antigens are tumour antigens with limited expression in male germ cells in the testis, ovary and trophoblasts. Recently, their expression has been seen in different types of tumours. Due to the existence of the blood-testis barrier, testis is considered an immune-privileged site; and testis-specific genes, if expressed in cancers, can be immunogenic. For this reason, cancertestis antigens are promising candidates for cancer immunotherapy and have become a major focus for the development of vaccinebased clinical trials in recent years. These antigens may be used as biomarkers for early detection of cancers. Expression of these genes in cancer reflects gene reprogramming and may have a role in neoplastic features such as metastasis and immune evasion.

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تاریخ انتشار 2011